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HIV Pharmacokinetic Research
There is a requirement to tailor HIV therapy to local po
pulations and healthcare settings as there is essentially no data on the pharmacology of antiretroviral drugs in African patients who are genomically, environmentally and behaviourially different to their Caucasian counterparts in whom these drugs were developed, researched and shown to be efficacious.
Pharmacokinetic evaluation i.e. measuring the blood concentration of antiretroviral therapy in a HIV-infected individual at a number of intervals over the day provides the information to address this challenge.
Current research questions
What is the appropriate dose of antiretroviral therapy in a patient who is concurrently being treated with TB medication?
What is the appropriate dose of antiretroviral therapy in a patient who is concurrently taking local herbal medicines?
Do generic antiretrovirals produce the same concentration of drug as branded antiretrovirals in the blood of an HIV-infected individual?
What is the appropriate dose of antiretroviral therapy in low weight African adults and adolescents?
This program of work is conducted by staff and associates of Realta with project based funding.
Details of research programme coming soon...
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